News

May 2024

We are very happy to announce a change in the inclusion criteria for the TUBA-WISP II study. From this point forward, also PALB2 PV carriers can be included. The other included pathogenic variants remain the same: BRCA1, BRCA2, RAD51C, RAD51D and BRIP1.

The lifetime risk for ovarian cancer with a PALB2 PV ranges from 3-5% and a risk-reducing surgery can be considered when the lifetime risk is >5%. Individual factors influence the personal risk assessment, and therefore we decided to also include the PALB2 PV carriers that are eligible for risk-reducing surgery. We recommend to consider for every individual patient whether or not the benefits of risk-reducing surgery outweigh the risks. An individual risk assessment tool could be used to quantify the ovarian cancer risk (like CanRisk).

March 2024

At the European Society for Gynaecological Oncology conference (ESGO) we held the TUBA-WISP II invesitgators meeting! We were very happy to welcome a lot of the participating centres and to discuss the study with everyone.